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Molecular Biology of Primary Carnitine Deficiency The SLC22A5 (OCTN2) gene is located on chromosome 5q31.1 and is composed of 11 exons that generate two alternatively spliced mRNAs encoding proteins of 581 amino acids (isoform a) and 557 amino acids (isoform b)

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Key interventions include: Dietary changes : Mediterranean-style diet rich in vegetables, whole grains, lean proteins, and healthy fats Regular physical activity : At least 150 minutes of moderate-intensity exercise weekly Alcohol intake : For NAFLD, adhere to UK Chief Medical Officers' low-risk drinking guidelines (no more than 14 units per week, spread over three or more days)

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