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2 Methods A comprehensive literature search was performed using PubMed, Scopus, and Web of Science databases from their inception through June 2024

[12] Very high cumulative exposure over months may encourage calcium deposition in soft tissues such as the renal parenchyma or coronary arteries, an outcome implicated in observational studies linking supra-physiological 25-hydroxyvitamin D levels with vascular calcification and heightened fracture risk in frail elders

doi: 10.1016/j.jid.2024.01.007 42 WongPMYangLYangLWuHLiWMaXet al

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Because side effects are real, costs are high, and long-term data is still evolving