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Although a significantly elevated renal CAT activity in 6- and 16-week old, 22 and older SHR 8, 23 has been reported before, this is the first time that altered renal CAT expression and activity has been reported in pre-hypertensive SHR

Garcia-Webb said decreasing a patients dose, switching them to a different medication or starting them on an additional one to help with nausea or excess stomach acid can help manage the side effects

In the present study, SR4 treatment led to a significant 13% reduction in BW in db/db mice across 5 weeks

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