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Women with PCOS frequently exhibit deficiencies in various vitamins and minerals, which are closely associated with the syndromes characteristic insulin resistance (IR) and endocrine disturbances

The potential to counteract these effects has been demonstrated with IL-1 receptor antagonists, which have been shown to improve glucose tolerance and enhance insulin production [571]

Bernardini R, Kamilaris TC, Calogero AE, Johnson EO, Gomez MT, Gold PW, Chrousos GP

These findings are consistent with previous reports linking TMRE loss to decreased oxygen consumption rate (OCR), further supporting the conclusion that SYNCRIP depletion disrupts mitochondrial function and metabolism [37]

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