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Alternatively, when isotopic labeling is infeasible, unlabeled metabolomics and/or targeted biochemical assays can detect correlative changes in total off-target metabolite levels, while epistasis studies with multiple genetic and/or pharmacological manipulations can allow causal assessment of whether probable metabolic off-targets are required for given physiological or behavioral readouts

When to Consider Vitamin B12 Treatment If symptoms continue or become more severe, starting Vitamin B12 treatment can correct deficiency, improve symptoms, and support overall health

it has not been tested in a human clinical trial

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