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Clinical data from the STEP trials, which enrolled over 4,500 participants, demonstrated that patients who followed standard titration achieved higher cumulative weight loss and continued treatment longer than those reporting accelerated schedules

Under FDA guidance documents and Chemical Safety Board recommendations, research-use-only (RUO) designation applies to chemical reagents, biological specimens, and investigational compounds sold exclusively for in vitro studies, animal research models, or mechanistic investigations conducted under controlled laboratory conditions

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These include severe abdominal pain (possible pancreatitis), changes in vision, signs of thyroid tumors (lump in the neck, difficulty swallowing, hoarseness), severe allergic reactions, and signs of rebound effects after stopping