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Update to a position statement of the American Diabetes Association and the European Association for the study of diabetes

This pattern is broadly consistent with a model in which semaglutide alters reward prediction errors or the valuation of behavioral outcomes, thereby reducing the anticipatory salience or hedonic impact of voluntary movement

[ [PMID: 36801984] [ [PMID: 37575352] et al

Cancer-related fatigue can persist well beyond the end of chemotherapy and be associated with cognitive and functional decline, insomnia, depression, and a reduction in the quality of life (107)

This suggests that long-term or potentially indefinite use may be necessary for sustained results, making total treatment cost over multiple years an important consideration when deciding whether Ozempic or alternatives are financially sustainable