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Many authors have suggested that the melanomas, which develop from an existing or pre-existing pigmented lesion usually undergo molecular changes (like melanocytic hyperplasia) induced by chemicals, stress, etc., or can be spontaneous or iatrogenic, before taking the form of an aggressive melanoma

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1 Department of Health Sciences, University of York, York, 2 School of Psychology, University of Leeds, Leeds, 3 School of Medicine, University of Leeds, Leeds, 4 University Hospital Southampton NHS Foundation Trust, Southampton, 5 Division of Psychology and Mental Health, University of Manchester, Manchester, UK