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Analyses used SAS version 9.3 mixed-effects regression models to estimate the effect and effect size of the treatment (Laird and Ware, a priori hypothesis that the change in the metabolic biomarker was greater for participants who underwent treatment as compared with the placebo group

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Briefly, SCD Day 10 erythroblasts were cultured at indicated conditions, and Cystine-FITC was added to cultured SCD erythroblasts at 100 M for 45 min, allowing uptake

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