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B12 is water-soluble, and excess is excreted in urine

Anti-anxiety effects in rats at 0.5 g/kg (extremely low dose) produced effects within 12 minutes of intraperitoneal injection, including increased time exploring open/lighted maze areas, decreased immobile freeze reaction time, and increased exploration in open field tests

Mice were monitored weekly for palpable tumors, commencing at an age of 8 weeks

A 2023 study revealed that HSV-1 infection enhances the ubiquitination and degradation of NRF2 by the E3 ubiquitin ligase Keap1, disrupting cellular redox homeostasis and promoting ferroptosis in the mouse central nervous system

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