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In contrast, each unit increase in proportion of energy from fat was significantly associated with lower BMI (0.808 kg/m 2 , 95% CI: 1.314 to 0.303 kg/m 2 ), lower FBG (0.770 mmol/L, 95% CI: 1.370 to 0.170 mmol/L), lower HbA1c (0.969%, 95% CI: 1.476% to 0.462%), lower 2hPPG (1.954 mmol/L, 95% CI: 1.476 to 0.462 mmol/L), lower AUC for serum insulin (1,135.1 IU/ml min, 95% CI: 2,193.8 to 76.4 IU/ml min) but higher WBISI (2.673, 95% CI: 0.0594.758)

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Likewise, the hypothalamic mTOR/S6K1 pathway has also been involved in the control of feeding and in the regulation of energy balances