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Some supplements may lower the effectiveness of medication." Always discuss new supplements with your healthcare provider or pharmacist for personalized guidance

As a synthetic analog of its endogenous exendin-4, compared with exendin-4, LIXI deleted one proline and added six lysine residues, which increased its binding affinity with the GLP-1R by four times and increased its circulating half-life (58, 59)

Further large, adequately powered trialsparticularly in neurology and systemic supplementationare needed to confirm efficacy and define optimal formulations, dosing, and safety profiles

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