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This burden of ROS-induced oxidative stress in the nervous system may be the cause of paralysis and eventual death of the adult worms because oxidative stress in the nervous system has been reported in numerous studies to cause adverse and irreversible modifications of the cellular macromolecular machinery and eventual death of the cell, including neurodegeneration through multiple mechanisms[8486]

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This is where the HypothalamicPituitaryOvarian (HPO) axis comes in

GLP-1s have already demonstrated a track record of safety and mortality reduction that can benefit a large percentage of the population, many of whom have a substance use disorder