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One study registered in Clinicaltrials.gov found that oral supplementation of glutathione significantly increased whole-body insulin sensitivity, showing that glutathione may be an effective supplement when it comes to regaining insulin sensitivity in those who are diabetic or obese

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Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans

Conversely, statins also exert beneficial mitochondrial effects, such as reducing mtDNA damage in atherosclerotic plaques and improving endothelial mitochondrial function via upregulation of eNOS