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GSH is necessary for the transformation of prostaglandin H2 into prostaglandin D2, which is also important in leukotriene synthesis

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Expression of system x c was positively correlated with ER expression, and predicted the poor outcome of ER+ breast cancer To investigate how ER regulates ferroptosis in ER+ breast cancer cells, we conducted an analysis of ferroptosis-related genes that are also regulated by estrogen

They are connected by a flow of glutamine (produced directly from glutamate, generated as discussed below) from astrocytes to neurons