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Description

AARS1 binds directly to lactate, catalyzes the adenosine triphosphate (ATP)-dependent synthesis of lactate-AMP and mediates widespread lysine lactylation, including that of p53

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Modifications such as the substitution of tyrosine at the N-terminus appear to improve its stability compared to the native sequence

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Abstract Glutathione (GSH) is a small-molecule thiol that is abundant in all eukaryotes and has key roles in oxidative metabolism 1

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