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It works through several mechanisms, such as suppressing appetite, increasing satiety, reducing food cravings and feelings of hunger, and delaying gastric emptying (the rate at which the stomach empties)

Paracetamol glucuronidation by recombinant rat and human phenol UDP-glucuronosyltransferases

All TPP-dependent enzymes contain a highly similar TPP-binding domain and its lack in the TKTL1 encoded protein strongly suggests that it is unlikely that TKTL1 is a TPP-dependent protein capable of catalyzing the transketolase reaction

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Additionally, GLP-1 receptor agonists act on appetite-regulating centers in the hypothalamus, reducing hunger signals and promoting weight loss