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J Cell Biol 211:11031111 Colello D, Mathew S, Ward R, Pumiglia K, LaFlamme SE (2012) Integrins regulate microtubule nucleating activity of centrosome through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signaling

Arthritis Care Res 2010

Rovamo LM, Salmenpera L, Arjomaa P, et al

Multiple in vitro studies have demonstrated that NAC actively induces the non-immunological degranulation of mast cells, causing them to dump pre-formed histamine directly into the bloodstream, which can trigger immediate allergic-type symptoms

You should also understand how dose changes work and whether labs or blood pressure checks are needed during treatment