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Notably, efficient fatty acid metabolism, particularly beta-oxidation for energy production, requires adequate levels of L-carnitine, which acts as an essential cofactor for transporting long-chain fatty acids into the mitochondria

Conversely, it has been shown that increased NCOA4 by knockdown of COPZ1 (coatomer protein complex subunit zeta 1) results in the degradation of ferritin and induction of ferroptosis in GBM [132]

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In vitro challenge with Mycobacterium avium demonstrated enhanced immune clearance post-treatment, suggesting that glutathione primes immune defense mechanisms relevant to neuroinflammatory conditions