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Up-regulation of the PPP flux provides cells with R5P for nucleotide biosynthesis, as well as NADPH for biosynthesis and maintaining redox homeostasis (59, 67, 70)

Alzheimers disease Alzheimer's disease (AD) is defined by the degeneration of synapses and neurons in the cerebral cortex and some subcortical sites, resulting in atrophy and degeneration of the affected regions in the temporal and parietal lobes, as well as portions of the callosal gyrus and the frontal lobe (Das et al., 2021, Kabir et al., 2021)

One critical detail: supplementing GlyNAC for 24 weeks reversed multiple defects in older adults, but stopping GlyNAC for 12 weeks led to redevelopment of those defects

On pages he's checked, you'll see his reviewer card