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Glutamine-derived aspartate induced by GOT2 is transported into the cytosol and converted by GOT1 to oxaloacetate, then converted by malate dehydrogenase (MDH1) into malate and subsequently oxidized into pyruvate by ME1 to create NADPH

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Pain in the upper abdomen or right upper abdomen, fever, nausea, vomiting, and bloating are frequent symptoms [17]