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The simultaneous presence of pharmacological efficacy and toxicity necessitates careful evaluation, as some adverse effects may outweigh their therapeutic benefits (Nagahama et al., 2016

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Nevertheless, as discussed above, an abnormal postmethionine-load homocysteine elevation above fasting levels must be taken into account in the general identification of patients bearing transsulfuration defects, such as vitamin B 6 -deficient subjects or heterozygotes for CBS deficiency