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doi: 10.1172/JCI101213

Our findings demonstrated a significant reduction in the risk of MACE and HHF among patients using SGLT-2i or GLP-1 RAs, regardless of whether they were already taking metformin

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Antioxidant - a compound that prevents or repairs the damage caused by reactive oxygen species Antioxidant enzymes - enzymes that contribute to neutralizing atoms or molecules capable of damaging essential cell constituents Artery (adj: arterial) - a muscular-walled blood vessel that carries blood away from the heart Diuretic - an agent that increases the formation of urine by the kidneys, resulting in water loss from the individuals using the diuretic Inverse association - a relationship between two variables in which they move in opposite directions Nitric oxide - a gaseous signaling molecule

Note that trial durations differ and head-to-head comparisons are not yet available