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More recent evidence on the effect of incretin-based therapies in HFpEF comes from the SUMMIT trial assessing the effect of the dual GLP-1RA/GIPRA tirzepatide versus placebo in 731 patients with heart failure, an ejection fraction of at least 50%, and a BMI of at least 30 kg/m 2

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ALC also maintains healthy body fat and muscle composition in aging individuals