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Injecting into muscle by accident can cause faster absorption than intended, more discomfort, and a higher chance of side effects

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The observation that mild GO rarely progresses and often spontaneously remits was recently confirmed by a large prospective study of patients with recent onset Graves hyperthyroidism (17) and summarized in a review of published studies (24)

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The first completed trial, TRIUMPH-4, reported results in December 2025 showing 28.7% average body weight loss at 68 weeks on the 12mg dose