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If you are going to experience a problem with heart rate on retatrutide, it will most likely manifest during this window

10.1254/jphs.95.19 46 LozicM.StambolijaV.KrezicI.DugandzicA.Zivanovic-PosilovicG.GojkovicS.et al (2020)

The non-randomized trial by Pettegrew et al 12 assessed with ROBINS-I, showed a critical risk of bias from confounding and serious risk from participant selection, although other domains were low risk

Injections are typically self-administered with a small, easy-to-use syringe