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What is the age limit for Glucagon-like peptide-1 (GLP-1) analogues, such as liraglutide (Victoza), semaglutide (Ozempic), or dulaglutide (Trulicity), for patients with type 2 diabetes?

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Supporting this possibility, preclinical studies have reported that setmelanotide can effectively restore MC4R activity in obese animal models harboring LOF MC4R variants, thereby reducing food intake and increasing total energy expenditure, which results in significant weight loss

Trends Endocrinol Metab 2018;29:23848.ArticlePubMed 38

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