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Morris D, Ly J, Chi PT, et al

In addition, the kynurenine pathway, influenced by pro-inflammatory cytokines, has been implicated in the depletion of neuroprotective factors, thus contributing to the neurodegenerative aspects of depression [105]

SGLT2-i Initiation and Insulin De-Escalation In a retrospective cohort study by Champion et al., initiation of SGLT2-ioften in combination with metformin and/or a GLP-1 receptor agonistled to significant reductions in both insulin dose and overbasalization rates