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Extensive persistent inflammation even when SARS-CoV-2-infected cells are only sporadically present at late stages of COVID-19 (Schurink et al., 2020) could also justify low GSH levels in association with over-abundance of cellular ROS, cellular oxidative damage, increased inflammation and cell death pathways activation seen in inflammaging (Zuo et al., 2019

2005 Jul;146(7):3052-8

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Symptoms could include nausea, diarrhoea and abdominal cramps

Metformin, a biguanide derivative, has been a mainstay in treating type 2 diabetes for over six decades, primarily through inhibiting hepatic gluconeogenesis and increasing muscle insulin sensitivity