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The question has gained visibility due to anecdotal accounts of so-called Ozempic babies. This paper aims to delineate mechanisms linking GLP-1 receptor activation with reproductive outcomes, review clinical data on fertility, and outline implications for practice

These residues are located within the upper and central regions of the TM2 and TM3 bundle and have been recurrently associated with ligand recognition in active-state GLP-1R structures (Zhao et al., 2020)