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Where appetite is the dominant driver of weight: the GLP-1/GIP dual mechanism of tirzepatide already addresses appetite and satiety powerfully, and adding a third receptor may offer diminishing marginal benefit for this specific lever

Although GLP-1 receptor agonists have demonstrated effectiveness in reducing weight loss and risks for other chronic diseases, questions remain over whether the benefits outweigh the harms of the drugs, including their cost-effectiveness and economic impact, Hannah Moll, a PhD candidate from the department of epidemiology at the University of Zurich in Switzerland, and colleagues, wrote in eClinicalMedicine

Patients with UC for an extended period often suffer from malnutrition or anemia due to insufficient dietary intake

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