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Serum uric acid and risk of dementia in Parkinsons disease

Horn M, Denzel SI, Srinivasan B, Allmeroth K, Schiffer I, Karthikaisamy V, Miethe S, Breuer P, Antebi A, Denzel MS (2020) Hexosamine pathway activation improves protein homeostasis through the integrated stress response

Some inconsistent results in past trials (for cognitive outcomes) may relate to using melatonin in advanced disease stages or issues with absorption in older people

The crystal structure of the protein is shown in Fig

22 Collectively, these findings establish HSPs, particularly members of the sHSP family, as central determinants of cardiac proteostasis, structural stability, and stress resilience