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The reassurance does not change clinical advice

There were no unexpected safety findings at the Phase 2 stage that would fundamentally alter the risk-benefit profile expected for this class

Figure 4 In summary, melatonin plays a pivotal role in regulating female reproductive hormone secretion and the menstrual cycle rhythm through its complex interactions with the hypothalamic-pituitary-ovarian (HPO) axisEnvironmental light exposure, patterns of melatonin secretion, and the dynamics of receptor expression collectively contribute to the maintenance of endocrine balance and physiological functions within the female reproductive system (78, 79)

We weve talked a lot about the need for this holistic model, and its interesting to look at the data