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Key Facts Roche said patients taking its experimental once-daily oral drug, CT-996, for four weeks lost an average of 6.1% of their starting bodyweight compared to patients who received a placebo

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Referral to cardiology is appropriate for patients with: Uncontrolled hypertension (160/100 mmHg) despite multiple medications Recent cardiovascular events (within 6 months) Symptomatic heart failure Complex arrhythmias Significant valvular disease Shared decision-making should incorporate discussion of expected weight loss magnitude, potential cardiovascular benefits including blood pressure reduction, common adverse effects (nausea, diarrhea, constipation), cost considerations, and the need for long-term treatment to maintain benefits