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To model Leydig cell senescence in vitro, TM3 mouse Leydig cells were treated with hydrogen peroxide (H2O2)

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S is the main component of Lewy bodies and is a pathogenic feature of all synucleinopathies, including Parkinsons disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA)

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Some of the most commonly reported adverse effects with these new therapies are cutaneous, and can potentially limit the use of these agents and add cost to already expensive treatment regimens.1 It is important for physicians and other healthcare providers to be aware of these effects, have a basic understanding of how to manage patients with these reactions, and to know when to refer to a dermatologist