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Even reduced doses of GLP-1 medications may not provide adequate appetite suppression, and the transition period often triggers compensatory eating behaviors

Tapering Off GLP-1 Medications Pinto says people taking a GLP-1 who want to adjust their dosing for whatever reason finances, changes in insurance coverage, or they no longer want to be on the medication should talk with their doctor about the best path forward

According to Alkhaddo, even though these oral agents may not be as effective as GLP-1s, they may be a good choice to help patients maintain their weight

In June 2025, WeightWatchers shared data from 200 individuals who discontinued GLP-1 medications while following structured lifestyle plans

doi: 10.1002/oby.24302