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A meta-analysis of placebo-controlled clinical trials assessing the safety and efficacy of incretin-based therapy showed that the GLP-1 analogues are more effective in lowering blood glucose and weight loss, whereas sitagliptin lowers blood glucose levels to a lesser degree and are weight neutral [20]: the results showed that unadjusted HbA1c changes for exenatide, liraglutide, and sitagliptin are 0.75% (0.83, 0.67), 1.03% (1.16, 0.90), and 0.79% (0.93, 0.65), respectively

Moreover, further studies suggested that BPC-157 regulated the phosphorylation level of extracellular signal-regulated kinases 1 and 2 (ERK1/2) as well as its downstream targets, including c-Fos, c-Jun, and Egr-1, which are key molecules involved in cell growth, migration, and angiogenesis

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Farag et al., 2022

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