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Using bioinformatics, we also found that the human protein TOMM40L (an outer mitochondrial membrane 40 homolog like translocase) contains a strong homology of six contiguous amino acids to the TMV coat protein, and TOMM40L peptide exhibited cross-reactivity with anti-TMV antibodies

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Additionally, it has been proposed that alterations in both mtDNA and nuclear DNA (nDNA) encoding mitochondrial genes may affect mitochondrial metabolite production, which, in turn, could modify the epigenome and regulate nDNA gene expression [180, 184,185,186]

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