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E-cigarettes have not been evaluated by the United States Food and Drug Administration (FDA), and the levels of nicotine or other chemicals they contain are unknown

Ram Manohar, "Smoking and Ayurvedic Medicine in India" in Smoke , pp

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[7] Validating this product formulation strategy, researchers have found study participants preferred salt-based nicotine over freebase nicotine, noting it was smoother and less harsh, with the greatest appeal among those who never smoked cigarettes