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Due to the increase in use, science may need time to catch up on the side effects as in, to determine both short-term and long-term side effects as the drugs are used for different conditions and for longer periods of time

If not treated, intestinal obstructions could cause death of the surrounding tissue and infection of the abdominal cavity (peritonitis)

Long-term PPI use carries known risks including reduced B12 and magnesium absorption, increased fracture risk, and potential alterations in gut microbiota diversity