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From a safety perspective, gastrointestinal adverse effects are the most commonly reported for GLP-1 RAs, with nausea, vomiting, and diarrhea remaining the leading causes of treatment discontinuation [7]

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Ketone bodies have been shown to increase T cell functions such as production of cytokines and cytolysis by not only providing a source of energy but also by regulating histone acetylation at effector gene loci (72)

Several clinical scenarios warrant professional evaluation