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Cytosolic enzymes protect the matrix against both exogenous and mitochondriaderived H 2 O 2 The smaller roGFP2Tsa2C R response in the matrix compared to the cytosol could be explained by either (i) efficient cytosolic scavenging systems as well as the two mitochondrial membranes limiting the amount of H 2 O 2 that reaches the matrix or (ii) by more efficient scavenging of H 2 O 2 in the matrix limiting the amount of H 2 O 2 available to react with the probe
All authors approved the final version of the manuscript for submission
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