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In a phase 2 trial, once-weekly cagrilintide produced dose-dependent weight reductions in people with overweight or obesity, which is what moved the amylin pathway into serious combination development ( Lau et al., Lancet 2021 )

UK regulators have also signalled concern about peptide-related health claims in this space

All of these subjects had numerous repeat exposures to the product without recurrence of the events and a causal relationship between the antibody findings and these clinical events has not been established

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Results are indicated as absolute frequency (N) or mean values and respective standard deviations (SD)