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On the other hand, a significant increase in TDO expression has been found in preeclampsia, but since inflammatory response is involved in the pathogenesis of preeclampsia, it can be hypothesized that upregulation of TDO cannot fully compensate for the decrease in IDO in this regard

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It is a melatonin modification originally developed alongside Melanotan 1 peptide at the University of Arizona in the 1980s