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Historically, PAs were implicated in the etiology of schizophrenia because certain antipsychotic and antimalarial drugs contain structural components resembling spermidine and were associated with extrapyramidal symptoms and psychosis (84)

Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) based on Sirtuin Rearranging Ligands (SirReals)

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