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J Craniomaxillofac Surg (2018) 46:2016

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Meal intake decreased bilateral insula activation, and GLP-1R antagonist reversed the meal-induced reductions in the bilateral insula activity in response to high-energy food, in addition to leading to increased hunger scores (Jennifer et al., 2016)

The cancer cell population can arise spontaneously or by such processes as mutations present in the germline of the host animal or somatic mutations, or it can be chemically-, virally-, or radiation- induced