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While GHK-Cu treatment alone did not cause any visible histological changes or toxicity, pretreatment with GHK-Cu markedly attenuated these pathological alterations, resulting in a significantly reduced lung injury score compared to the LPS-only group

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Research in pituitary biology has demonstrated that simultaneous activation of both the ghrelin and GHRH receptor pathways produces a synergistic amplification of GH secretion that exceeds the additive effect of activating either pathway alone