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62, 63, 64 Recent studies using the whole-body or mucosal epithelial-specific deletion of claudin-7 support such a postulation

(2023) 130:9399.e10

This higher dose did produce more gastrointestinal side effects, but the additional weight loss was statistically significant

GLP-1RA treatment also mitigates experimental diabetic cardiomyopathy by the indirect mechanisms of augmenting glucose oxidation in cardiomyocytes [84]

Contrasting results (to the IMPALA study) were obtained by Esposito et al