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Stephen Appezzato Key Takeaways Federal exclusion of weight-loss drugs forces Medicare GLP-1 utilization into other FDA-approved indications, even as 2024 Part D gross GLP-1 spending reached $27.5 billion across 21.8 million claims

In addition to discussing the weight loss efficacy of semaglutide, the recently published results of CV outcome trials will be addressed later in this paper

Patients should contact their healthcare provider promptly if they develop jaundice yellowing of the skin or whites of the eyeswhich may indicate significant liver dysfunction or bile duct obstruction

Obesity and MAFLD interact, leading to a vicious cycle with one leading to another