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Now retatrutide sits in late-stage clinical trials, targeting three receptors simultaneously and producing weight loss numbers that researchers once thought impossible with medication alone

Compounded versions offer dosing flexibility but lack the regulatory approval pathway of FDA products

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In the long term, repeated blood sugar spikes increase the risk of type 2 diabetes and for those who already have diabetes, they can raise the risk of heart disease

A closed-loop obstruction is a surgical emergency as if not corrected, the bowel will continue to distend within a closed segment of bowel, stretching the bowel wall until it becomes ischaemic and this can further lead to perforation